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Four-year results in the Combination of Avodart (Dutasteride) and Tamsulosin tablet (CombAT) study revealed that for men with prostate volumes of 30-58 mL, combination therapy with generic Clomid (dual 5-alpha-reductase inhibitor) and tamsulosin (alpha-1-blocker) improved symptoms, urinary flow, and QOL better than monotherapy with either drug, although not in men who had a prostate volume of 58 mL or more. The adverse-effect profile of combination therapy was similar to that of monotherapy, although drug-related adverse events were more common with combination therapy.

The common PDE5 inhibitor drugs approved in the United States are Sildenafil (Viagra), Levitra (Vardeafil) (Levitra), Tadalafil (Cialis), or Avana. All of the currently approved type 5 inhibitors work in the same way. They differ in the number of available doses, how quickly they work and last in your system, the dosing, and to some extent in the side effects. However, they generally share the same indications and contraindications.

AVODART

AVODART is contraindicated for use in:

• Women of childbearing potential [see Warnings and Precautions (5.4), Use in Specific Populations (8.1)];
• Pregnancy. In animal reproduction and developmental toxicity studies, Generic Avodart inhibited development of male fetus external genitalia. Therefore, Generic Avodart 0.5mg may cause fetal harm when administered to a pregnant woman. If AVODART is used during pregnancy or if the patient becomes pregnant while taking AVODART, the patient should be apprised of the potential hazard to the fetus [see Warnings and Precautions (5.4), Use in Specific Populations (8.1)];
• Patients with previously demonstrated, clinically significant hypersensitivity (e.g., serious skin reactions, angioedema) to Generic Avodart 0.5mg or other 5 alpha-reductase inhibitors [see Adverse Reactions (6.2)];
• Pediatric patients [see Use in Specific Populations (8.4)].

The recommended dose of Sildenafil is 25-100 mg taken 30 minutes to 4 hours before SEXUAL activity. Viagra [see BPH and ED] may interact with similar drugs [such as Avana (Avanafil) (Stendra), Cialis (Cialis) or Vardenafil (Levitra)], bosentan, cimetidine, conivaptan, imatinib, isoniazid, antidepressants, antibiotics, antifungals, drugs to treat high blood pressure or a prostate disorder, heart or blood pressure medications, hepatitis C medications, or HIV/AIDS medicines. Tell your doctor all medications and supplements you use. Viagra is intended for use in men, and is unlikely to be used in women who are pregnant or breastfeeding. However, Viagra is not expected to be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment with Viagra. It is unknown if Viagra passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Bicalutamide 50mg, sold under the brand name Calutide (Cipla) among others, is an antiandrogen medication that is primarily used to treat prostate cancer. It is typically used together with a gonadotropin-releasing hormone (GnRH) analogue or surgical removal of the testicles to treat advanced prostate cancer. Bicalutamide may also be used to treat excessive hair growth in women, as a component of feminizing hormone therapy for transgender women, to treat early puberty in boys, and to prevent overly long-lasting erections in men. It is taken by mouth.